Cagliari vs Lazio: Lineups, Predictions & Betting Tips

Serie A Preview: Cagliari vs Lazio

The Unipol Domus is set to host an intriguing matchup between Cagliari and Lazio on Saturday, February 21,2026,19:45 GMT. Recent form suggests that Cagliari may have a slight edge over their opponents, but Lazio's historical success against them cannot be overlooked.

Looking back at their head-to-head encounters, it becomes clear that Lazio has traditionally had the upper hand. Their most recent meeting in November 2025 saw Lazio claim a convincing 2-0 victory. However, the home side has shown resilience in their recent performances and are tipped to potentially turn the tide.

Tactically, Cagliari will likely look to assert their dominance at home by leveraging the support of their fans. Lazio on the other hand will aim to exploit any weaknesses in Cagliari's defense to grab a vital away win.

Given the projected outcomes and bookmaker odds, it appears that this fixture could go either way. With Cagliari being narrowly favored to win or potentially sharing the spoils with a draw against their name-sakes it will be interesting to see how both teams navigate the ninety minutes.

The visitors have shown an ability to score against Cagliari in past meetings and may look to capitalize on the home side's mistakes. Yet with nearly two-thirds of recent predictions pointing towards a low-scoring contest it may be that both teams could find the back of their opponent's net only a handful of times.

Ultimately this promises to be an absorbing contest at the Unipol Domus with both teams having everything to play for. Will Cagliari's home advantage prove decisive or can Lazio upset the odds and claim a crucial victory on the road?